RÉSUMÉ
Objectif
Population cible
Options
Résultats
Bénéfices, risques et coûts
Données probantes
Méthodes de validation
Professionnels concernés
ABRÉVIATIONS:
ALPS (Antenatal Late Preterm Steroids (corticothérapie prénatale en période de prématurité tardive)), CTP (corticothérapie prénatale), ECMO (oxygénation par membrane extracorporelle), ECR (essai clinique randomisé), HIV (hémorragie intraventriculaire), IC (intervalle de confiance), OMS (Organisation mondiale de la Santé), RC (rapport de cotes), RCa (rapport de cotes ajusté), RR (risque relatif), SDR (syndrome de détresse respiratoire)Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Obstetrics and Gynaecology CanadaReferences
- Committee opinion no.677: antenatal corticosteroid therapy for fetal maturation.Obstet Gynecol. 2016; 128: e187-e194
- Society for Maternal-Fetal Medicine Consult Series #58: use of antenatal corticosteroids for individuals at risk for late preterm delivery: replaces SMFM Statement #4, implementation of the use of antenatal corticosteroids in the late preterm birth period in women at risk for preterm delivery, August 2016.Am J Obstet Gynecol. 2021; 225: B36-42
- Antenatal corticosteroids to reduce neonatal morbidity and mortality: Green-top Guideline No. 74.BJOG. 2022; 129: e35-60
- Antenatal corticosteroids for the late preterm infant and agnotology.J Perinatol. 2017; 37: 1265-1267
- Antenatal corticosteroids beyond 34 weeks gestation: what do we do now?.Am J Obstet Gynecol. 2016; 245: 420-430
- No. 364-antenatal corticosteroid therapy for improving neonatal outcomes.J Obstet Gynaecol Can. 2018; 40: 1219-1239https://doi.org/10.1016/j.jogc.2018.04.018
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.Cochrane Database Syst Rev. 2017; 3: CD004454
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.Cochrane Database Syst Rev. 2020; 12: CD004454
- Antenatal dexamethasone for early preterm birth in low-resource countries.N Engl J Med. 2020; 383: 2514-2525
- Antenatal betamethasone for women at risk for late preterm delivery.N Engl J Med. 2016; 374: 1311-1320
- Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials.BMJ. 2016; 355: i5044
- A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.Pediatrics. 1972; 50: 515-525
- Effect of antenatal betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks.J Gorga Uni Med Sci. 2010; 12: 18-23
- The effect of antenatal steroids on fetal lung maturation between the 34th and 36th week of pregnancy.Gynecol Obstet Invest. 2010; 70: 95-99
- Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial.BMJ. 2011; 342: d1696
- Effects of antenatal dexamethasone on respiratory distress in late preterm infant: a randomized controlled trial.Thai J Obstet Gynaecol. 2015; 23: 25-33
- Effect of antenatal steroids on respiratory morbidity of late preterm newborns: a randomized controlled trial.J Trop Pediatr. 2018; 64: 531-538
- Antenatal dexamethasone for late preterm birth: a multi-centre, two-arm, parallel, double-blind, placebo-controlled, randomized trial.EClinicalMedicine. 2022; 44101285
- Helping patients decide: ten steps to better risk communication.J Nat Cancer Inst. 2011; 103: 1436-1443
Hutcheon JA, Liauw J. Improving the external validity of Antenatal Late Preterm Steroids trial findings [e-pub ahead of print]. Paediatr Perinat Epidemiol doi: 10.1111/ppe.12856. Accessed on December 12, 2022.
International Patient Decision Aid Standards Collaboration. International Patient Decision Aid Standards (IPDAS) Collaboration. Available at: http://ipdas.ohri.ca/resources.html. Accessed on December 12, 2022.
- The screening and management of newborns at risk for low blood glucose.Paediatr Child Health. 2019; 24: 536-554
- Outcome at 2 years after dextrose gel treatment for neonatal hypoglycemia: follow-up of a randomized trial.J Pediatr. 2016; 170 (e51–2): 54-59
- Association of neonatal glycemia with neurodevelopmental outcomes at 4.5 years.JAMA Pediatr. 2017; 171: 972-983
- Association of neonatal hypoglycemia with academic performance in mid-childhood.JAMA. 2022; 327: 1158-1170
- Association between transient newborn hypoglycemia and fourth-grade achievement test proficiency: a population-based study.JAMA Pediatr. 2015; 169: 913-921
- Long-term neuropathological and/or neurobehavioral effects of antenatal corticosteroid therapy in animal models: a systematic review.Pediatr Res. 2020; 87: 1157-1170
- A growing dilemma: antenatal corticosteroids and long-term consequences.Am J Perinatol. 2022; 39: 592-600
- Evaluation of long-term outcomes associated with preterm exposure to antenatal corticosteroids: a systematic review and meta-analysis.JAMA Pediatr. 2022; 176e220483
- Neurodevelopmental outcome after a single course of antenatal steroids in children born preterm: a systematic review and meta-analysis.Obst Gynecol. 2015; 125: 1385-1396
- The influence of betamethasone and orciprenaline on the incidence of respiratory distress syndrome in the newborn after preterm labour.Br J Obstet Gynaecol. 1980; 87: 127-131
- Effects of antenatal dexamethasone administration in the infant: long-term follow-up.J Pediatr. 1984; 104: 259-267
- Randomized study of the effect of antenatal dexamethasone on growth and development of premature children at the corrected age of 2 years.Acta Paediatr. 1997; 86: 294-298
- Corticosteroid therapy for prevention of respiratory distress syndrome in severe preeclampsia.Am J Obstet Gynecol. 1999; 180: 1283-1288
- Short and long-term effects of antenatal corticosteroids assessed in a cohort of 7,827 children born preterm.Acta Obstet Gynecol Scand. 2009; 88: 933-938
- Health consequences of prophylactic exposure to antenatal corticosteroids among children born late preterm or term.Acta Obstet Gynecol Scand. 2012; 91: 1415-1421
- Antenatal corticosteroid administration and early school age child development: a regression discontinuity study in British Columbia, Canada.PLoS Med. 2020; 17e1003435
- Antenatal corticosteroid administration and attention-deficit/hyperactivity disorder in childhood: a regression discontinuity study.CMAJ. 2022; 194: E235-E241
- Antenatal corticosteroid therapy for fetal maturation.J Obstet Gynaecol Can. 2003; 25: 45-52https://doi.org/10.1016/S1701-2163(16)31081-7
- Antenatal corticosteroids and neurodevelopmental outcomes in late preterm births.Arch Dis Child Fetal Neonatal Ed. 2022; 107: 250-255
- When are observational studies as credible as randomised trials?.Lancet. 2004; 363: 1728-1731
- Neurodevelopmental disorders among term infants exposed to antenatal corticosteroids during pregnancy: a population-based study.BMJ Open. 2019; 9e031197
- Associations between maternal antenatal corticosteroid treatment and mental and behavioral disorders in children.JAMA. 2020; 323: 1924-1933
- Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5).JAMA Pediatr. 2013; 167: 1102-1110
- Outcomes at 2 years of age after repeat doses of antenatal corticosteroids.N Engl J Med. 2007; 357: 1179-1189
- Mid-childhood outcomes of repeat antenatal corticosteroids: a randomized controlled trial.Pediatrics. 2016; 138e20160947
- Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: an individual participant data meta-analysis.PLoS Med. 2019; 16e1002771
- Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.Cochrane Database Syst Rev. 2022; 4: CD003935
- Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.Pediatrics. 2004; 114: 373-377
- Physical development and medical history of children who were treated antenatally with corticosteroids to prevent respiratory distress syndrome: a 10- to 12- year follow up.Pediatrics. 1990; 86: 65-70
- Twenty year follow up of antenatal corticosteroid treatment.Pediatrics. 2000; 105: E77
- Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial.Lancet. 2005; 365: 1856-1862
- Antenatal steroid therapy and 5-year outcome of extremely low birth weight infants.Obstet Gynecol. 1989; 73: 743-746
- Antenatal corticosteroids and outcome at 14 years of age in children with birth weight less than 1501 grams.Pediatrics. 2000; 106: E2
- Antenatal dexamethasone has no adverse effects on child physical and cognitive development: a long-term cohort follow-up investigation.J Matern Fetal Neonatal Med. 2012; 25: 2369-2371
- Antenatal steroid exposure and heart rate variability in adolescents born with very low birth weight.Pediatr Res. 2017; 81: 57-62
- Antenatal corticosteroids and the renin-angiotensin-aldosterone system in adolescents born preterm.Pediatr Res. 2017; 81: 88-93
- Antenatal corticosteroids and cardiometabolic outcomes in adolescents born with very low birth weight.Pediatric Res. 2017; 82: 697-703
- Neurodevelopmental outcome of extremely premature infants exposed to incomplete, no or complete antenatal steroids.J Matern Fetal Neonatal Med. 2013; 26: 1542-1547
- Association of neurodevelopmental outcomes and neonatal morbidities of extremely premature infants with differential exposure to antenatal steroids.JAMA Pediatr. 2016; 170: 1164-1172
- Antenatal glucocorticoid treatment is not associated with long-term metabolic risks in individuals born before 32 weeks of gestation.Arch Dis Child Fetal Neonatal Ed. 2008; 93: F442-F447
- Antenatal glucocorticoid exposure and long-term alterations in aortic function and glucose metabolism.Pediatrics. 2012; 129: e1282-e1290
- Long term effects of antenatal betamethasone on lung function: 30 Year follow up of a randomised controlled trial.Thorax. 2006; 61: 678-683
- Antenatal steroid treatment reduces childhood asthma risk in very low birth weight infants without bronchopulmonary dysplasia.J Perinat Med. 2010; 38: 95-102
- Antenatal steroid exposure and pulmonary outcomes in adolescents born with very low birth weight.J Perinatol. 2013; 33: 806-810
- Antenatal steroid exposure, aerobic fitness, and physical activity in adolescents born preterm with very low birth weight.J Pediatr. 2019; 215: 98-106.e2
- Antenatal steroid therapy for fetal lung maturation: Is there an association with childhood asthma?.J Asthma. 2009; 46: 47-52
- Antenatal dexamethasone exposure in preterm infants is associated with allergic diseases and the mental development index in children.Int J Environ Res Public Health. 2016; 13: 1206
- Single course of antenatal steroids did not alter cortisol in preterm infants up to 18 months.Acta Paediatr. 2012; 101: 604-608
- Impact of antenatal synthetic glucocorticoid exposure on endocrine stress reactivity in term-born children.J Clin Endocrinol Metab. 2012; 97: 3538-3544
- Persistent effects of antenatal synthetic glucocorticoids on endocrine stress reactivity from childhood to adolescence.J Clin Endocrinol Metab. 2018; 104: 827-834
- No association of antenatal synthetic glucocorticoid exposure and hair steroid levels in children and adolescents.J Clin Endocrinol Metab. 2020; 105: 575-582
- Antenatal glucocorticoid treatment is associated with diurnal cortisol regulation in term-born children.Psychoneuroendocrinology. 2016; 72: 106-112
- Psychobiological effects of prenatal glucocorticoid exposure in 10-year-old-children.Front Psychiatry. 2012; 3: 104
- Antenatal corticosteroids: a reappraisal of the drug formulation and dose.Pediatr Res. 2021; 89: 318-325
- Neonatal and maternal outcomes of lower versus standard doses of antenatal corticosteroids for women at risk of preterm delivery: a systematic review of randomized controlled trials.J Obstet Gynaecol Can. 2021; 43: 74-81https://doi.org/10.1016/j.jogc.2020.02.127
- Effect of dexamethasone and betamethasone on fetal heart rate variability in preterm labour: a randomised study.BJOG. 1998; 105: 749-755
- Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial.Lancet. 2022; 400: 592-604
McDonald SD, Murphy K. Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS). Available at: https://clinicaltrials.gov/ct2/show/NCT05114096?term=SNACS&draw=2&rank=2. Accessed on Janurary 19, 2022.
Article info
Publication history
Publication stage
In Press Journal Pre-ProofFootnotes
MISE À JOUR TECHNIQUE DE LA SOGC
No 439, août 2023 (remplace No 364, septembre 2018)
La Société des obstétriciens et gynécologues du Canada (SOGC) a pour politique de passer le contenu en revue cinq ans après sa publication. Le document peut alors être archivé ou révisé pour refléter les nouvelles données probantes.
(In English: Technical Update No. 439: Antenatal Corticosteroids at Late Preterm Gestation)
Comité de médecine fœto-maternelle (2022) : James Andrews, Sheryl Choo, Elisabeth Codsi, Jillian Coolen, Amélie Guay, Janine Hutson, Venu Jain (président), Noor Niyar N. Ladhani, Heather Martin, Kirsten Niles, Christy Pylypjuk, Genevieve Quesnel, Karen Wong
Remerciements : Les auteurs souhaitent remercier la collaboratrice spéciale Prubjot Gill, M.S.I., Vancouver, C.-B.
Divulgations : Les auteurs ont fourni une déclaration de divulgation et aucun conflit d’intérêts n’a été déclaré. Chaque auteur déclare répondre aux critères du JOGC pour être désigné comme tel.
Mots-clés : hormones corticosurrénaliennes; grossesse; corticostéroïdes; accouchement prématuré
Subject Categories: Obstétrique, Médecine fœto-maternelle
Le présent document correspond au consensus clinique et scientifique en vigueur au moment de sa publication et est sujet à changement. Les renseignements qu’il contient ne doivent pas être considérés comme les seuls traitements ou les seules interventions applicables. Les établissements locaux peuvent modifier les recommandations. La SOGC conseille toutefois aux établissements de bien documenter de telles modifications.
Consentement éclairé : Chaque personne a le droit et la responsabilité de prendre des décisions éclairées relativement aux soins qu’elle reçoit en partenariat avec ses fournisseurs de soins de santé. Pour aider les patientes à faire un choix éclairé, il faut leur fournir un soutien et des renseignements fondés sur des données probantes, adaptés à leur culture et personnalisés. Il faut tenir compte des valeurs, croyances et besoins de chaque patiente en fonction de ses circonstances personnelles et respecter la décision finale de la patiente quant aux options de soins et de traitements.
Langue et inclusion : La SOGC reconnaît l’importance d’être pleinement inclusif. Par conséquent, les principes de rédaction épicène seront utilisés dans la mesure du possible lorsque le contexte s’y prête. Autrement, la SOGC continue d’utiliser l’écriture genrée en raison de sa mission de faire progresser la santé des femmes. La SOGC reconnaît et respecte les droits de chaque personne à qui le présent contenu pourrait s’appliquer, notamment les personnes transgenres, non binaires ou intersexes. La SOGC encourage les fournisseurs de soins de santé à s’engager dans une conversation respectueuse avec chaque patiente et patient relativement à son identité de genre et au pronom de genre de son choix, ainsi qu’à appliquer les présentes directives comme il convient pour répondre aux besoins de chaque personne.
Notation des semaines d’aménorrhée utilisée dans la présente mise à jour technique : La présente mise à jour technique suit la notation de l’âge gestationnel utilisée par l’Organisation mondiale de la Santé : le premier jour de la dernière menstruation est le jour 0 (de la semaine 0); ainsi, les jours 0 à 6 constituent la semaine 0 complétée, les jours 7 à 13 constituent la semaine 1 complétée, etc. Les auteurs appuient l’utilisation de la longueur céphalo-caudale au premier trimestre comme paramètre idéal pour déterminer l’âge gestationnel exact (conformément à la directive no 388 de la SOGC, Détermination de l’âge gestationnel par échographie) lorsqu’il s’agit d’envisager les recommandations de la présente mise à jour technique.
CHANGEMENTS RECOMMANDÉS AUX PRATIQUES
1. La corticothérapie prénatale continue d’être fortement recommandée jusqu’à 33 SA + 6 j lorsque l’accouchement est attendu dans les 7 jours.
2. Entre 34 SA + 0 j et 36 SA + 6 j, il y a lieu d’envisager la corticothérapie prénatale en fonction des risques absolus et des bénéfices spécifiques à la semaine d’âge gestationnel; il est possible de faciliter la prise en considération au moyen de l’outil d’aide à la décision clinique compris dans la présente mise à jour technique.
3. Entre 34 SA + 0 j et 36 SA + 6 j, la corticothérapie prénatale n’est pas recommandée en cas de grossesse compliquée par un diabète préexistant.
MESSAGES CLÉS
1. La corticothérapie prénatale en période de prématurité tardive diminue le risque de morbidité respiratoire néonatale, mais augmente le risque d’hypoglycémie néonatale.
2. Les bénéfices absolus de la corticothérapie prénatale diminuent pour chaque semaine de gestation supplémentaire en période de prématurité tardive (c.-à-d. entre 34 SA + 0 j et 36 SA + 0 j).
3. Les effets de la corticothérapie prénatale en période de prématurité tardive demeurent incertains en ce qui concerne le devenir neurodéveloppemental et les autres issues à long terme en raison de l’absence de données probantes directes sur ces issues.
Figure 2 (en attente). Outil d’aide à la décision clinique pour l’administration de la corticothérapie prénatale en période de prématurité tardive.
Identification
Copyright
ScienceDirect
Access this article on ScienceDirectLinked Article
- Technical Update No. 439: Antenatal Corticosteroids at Late Preterm GestationJournal of Obstetrics and Gynaecology Canada
