The rare occurrence of the failure to respond to ovulation trigger injection, leading
to the lack of oocyte recovery at the time of retrieval, termed “empty follicle syndrome”
(EFS), is a devastating event for both patient and clinician. The syndrome can be
subclassified as false EFS (fEFS) and genuine EFS according to low versus normal post-trigger
injection serum hormone levels, respectively.
1
fEFS is most commonly due to human error in administration or pharmacologic failure,
whereas genuine EFS is attributed to inherent pathophysiology, such as hormone receptor
polymorphism or zona pellucida mutations.To read this article in full you will need to make a payment
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References
- Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.Reprod Biomed Online. 2017; 35: 132-138
- Predicting successful induction of oocyte maturation after gonadotropin-releasing hormone agonist (GnRHa) trigger.Hum Reprod. 2013; 28: 152-159
- Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS.J Assist Reprod Genet. 2012; 29: 249-253
Article info
Publication history
Published online: November 18, 2022
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© 2022 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.
