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Serum hormonal testing after ovulation triggering in ART - a survey of practice in Canadian IVF clinics

  • Jennia Michaeli
    Correspondence
    Corresponding Author: Jennia Michaeli, Department of Obstetrics and Gynaecology, University of Toronto 123 Edward St., Suite 1200, Toronto, Ontario M5G 1E2, Canada Phone: +1 (416) 586-4748
    Affiliations
    Mount Sinai Fertility, Sinai Health System, 250 Dundas St. West, Suite 700, Toronto, Ontario M5T 2Z5, Canada

    Department of Obstetrics and Gynaecology, University of Toronto, 123 Edward St., Suite 1200, Toronto, Ontario M5G 1E2, Canada
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  • Heather Shapiro
    Affiliations
    Mount Sinai Fertility, Sinai Health System, 250 Dundas St. West, Suite 700, Toronto, Ontario M5T 2Z5, Canada

    Department of Obstetrics and Gynaecology, University of Toronto, 123 Edward St., Suite 1200, Toronto, Ontario M5G 1E2, Canada
    Search for articles by this author
  • Ellen M. Greenblatt
    Affiliations
    Mount Sinai Fertility, Sinai Health System, 250 Dundas St. West, Suite 700, Toronto, Ontario M5T 2Z5, Canada

    Department of Obstetrics and Gynaecology, University of Toronto, 123 Edward St., Suite 1200, Toronto, Ontario M5G 1E2, Canada
    Search for articles by this author
Published:November 18, 2022DOI:https://doi.org/10.1016/j.jogc.2022.11.001
      The rare occurrence of failure to respond to ovulation trigger injection, leading to the lack of oocyte recovery at the time of retrieval, termed empty follicle syndrome (EFS), is a devastating event for both patient and clinician. The syndrome can be subclassified as false EFS (fEFS) and genuine EFS (gEFS) according to low versus normal post trigger-injection serum hormone levels, respectively(
      • Revelli A.
      • Carosso A.
      • Grassi G.
      • Gennarelli G.
      • Canosa S.
      • Benedetto C.
      Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
      ). False EFS is most commonly due to human error in administration or pharmacologic failure, while gEFS is attributed to inherent pathophysiology, such as hormone receptor polymorphism or zona pellucida mutations.

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      References

        • Revelli A.
        • Carosso A.
        • Grassi G.
        • Gennarelli G.
        • Canosa S.
        • Benedetto C.
        Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
        Reprod Biomed Online. 2017 Aug 1; 35: 132-138
      1. Kummer NE, Feinn RS, Griffin DW, Nulsen JC, Benadiva CA, Engmann LL. Predicting successful induction of oocyte maturation after gonadotropin-releasing hormone agonist (GnRHa) trigger. Hum Reprod [Internet]. 2013 Jan 1 [cited 2022 Jul 21];28(1):152–9. Available from: https://academic.oup.com/humrep/article/28/1/152/595946

      2. Castillo JC, Juan GV, Humaidan P. Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS. J Assist Reprod Genet [Internet]. 2012 Mar [cited 2022 Jul 21];29(3):249. Available from: /pmc/articles/PMC3288136/