Preeclampsia affects approximately 5% of pregnant women and is associated with serious
perinatal morbidity and mortality. Left untreated, and in its most serious forms,
preeclampsia leads to maternal vital organ damage, seizures, long-term cardiovascular
diseases, and potentially maternal death. Most of these adverse outcomes are associated
with maternal vascular malperfusion of the placenta, a disease that begins during
the first trimester when uteroplacental blood flow to the implantation site is increasing
exponentially. Because aspirin initiated in the first trimester of pregnancy has been
shown to improve placental perfusion and prevent preeclampsia, it is increasingly
used in various at-risk populations. However, care must be taken to respect the scientific
evidence regarding its optimal use.
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References
- Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis.Am J Obstet Gynecol. 2018; 218: 287-293.e1
- Differential inhibition of prostacyclin production and platelet aggregation by aspirin.Lancet. 1979; 2: 1213-1217
- Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia.N Engl J Med. 2017; 377: 613-622
- The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women.J Perinat Med. 2022; https://doi.org/10.1515/jpm-2021-0668
- Pilot interventional study comparing fetomaternal outcomes of 150 mg versus 75 mg aspirin starting between 11 and 14 weeks of pregnancy in patients with high risk of preeclampsia: A Randomized Control Trial.J Obstet Gynaecol India. 2020; 70: 23-29
- A Pilot Randomized Trial comparing the effects of 80 versus 160 mg of aspirin on midtrimester uterine artery pulsatility index in women with a history of preeclampsia.J Obstet Gynecol Can. 2020; 42: 1498-1504
Article info
Publication history
Published online: August 02, 2022
Footnotes
Disclosures: The authors declare they have nothing to disclose.
Each author has indicated they meet the journal’s requirements for authorship.
Identification
Copyright
© 2022 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.
