Advertisement
JOGC
SOGC CLINICAL PRACTICE GUIDELINE| Volume 43, ISSUE 11, P1334-1341.e1, November 2021

Download started.

Ok

Guideline No. 422d: Menopause and Sexuality

Published:September 15, 2021DOI:https://doi.org/10.1016/j.jogc.2021.09.005

      ABSTRACT

      Objective

      Provide strategies for improving the care of perimenopausal and postmenopausal women based on the most recent published evidence.

      Target Population

      Perimenopausal and postmenopausal women.

      Benefits, Harms, and Costs

      Target population will benefit from the most recent published scientific evidence provided via the information from their health care provider. No harms or costs are involved with this information since women will have the opportunity to choose among the different therapeutic options for the management of the symptoms and morbidities associated with menopause, including the option to choose no treatment.

      Evidence

      Databases consulted were PubMed, MEDLINE, and the Cochrane Library for the years 2002–2020, and MeSH search terms were specific for each topic developed through the 7 chapters.

      Validation Methods

      The authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online Appendix A (Tables A1 for definitions and A2 for interpretations of strong and weak recommendations).

      Intended Audience

      physicians, including gynaecologists, obstetricians, family physicians, internists, emergency medicine specialists; nurses, including registered nurses and nurse practitioners; pharmacists; medical trainees, including medical students, residents, fellows; and other providers of health care for the target population.

      SUMMARY STATEMENTS

      • 1
        Low sexual desire in combination with distress is most common in women in mid-life (high).
      • 2
        Vaginal atrophy is a common cause of sexual pain in menopausal women (high).
      • 3
        Sexual dysfunction in menopausal women can be categorized as disorders involving desire, arousal, pain, and orgasm. These categories often overlap (high).
      • 4
        A brief sexual history is part of the evaluation of menopausal women (moderate).
      • 5
        The treatment of sexual dysfunctions involves a multifaceted approach that addresses medical, psychological, and relationship issues (high).
      • 6
        Local estrogen therapy treats genitourinary syndrome of menopause (high).
      • 7
        Pelvic physiotherapy is an excellent adjuvant treatment for hypercontracted pelvic floor muscles (often referred to as vaginismus) and genito-pelvic pain (low).
      • 8
        Flibanserin has been shown to improve desire in women (moderate).
      • 9
        Transdermal testosterone has been shown to increase desire, arousal, and satisfying sexual events, and to decrease personal distress (high).
      • 10
        Psychological therapies, including cognitive behavioural therapy, mindfulness-based therapy, couples’ therapy, and sexual therapies, are useful for treating sexual dysfunctions (moderate).
      • 11
        Sexual dysfunction is common in patients with depression, those on selective serotonin reuptake inhibitors (SSRIs), women with primary ovarian insufficiency, and those with a history of breast cancer (high).

      RECOMMENDATIONS

      • 1
        The patient's problem should be categorized as related to desire, arousal, pain, or orgasm, in order to facilitate treatment and to triage care (strong, moderate).
      • 2
        Health care providers should include a sexual screening history and physical examination in the initial evaluation of menopausal women (strong, low).
      • 3
        Vaginal estrogens, lubricants and moisturizers, vaginal dehydroepiandrosterone, and ospemifene may be used as treatments for vaginal atrophy related to menopause (strong, high).
      • 4
        For postmenopausal women with hypoactive sexual desire disorder, the best current options include managing pain, addressing any biopsychological factors, counselling, and prescribing transdermal testosterone (off-label) or flibanserin (strong, moderate).
      • 5
        Patients with breast cancer and symptomatic genitourinary syndrome of menopause can be offered local vaginal estrogen if local lubricants and moisturizers are ineffective, after consulting with the patient's oncologist (conditional, moderate).

      Keywords

      ABBREVIATIONS:

      DHEA (dehydroepiandrosterone), FSAD (female sexual arousal disorder), GSM (genitourinary syndrome of menopause), PLISSIT (Permission, Limited Information, Specific Suggestions, and Intensive Therapy), HSDD (hypoactive sexual desire disorder), SSRI (selective serotonin reuptake inhibitors)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Obstetrics and Gynaecology Canada
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Nappi RE
        • Cucinella L
        • Martella S
        • et al.
        Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL).
        Maturitas. 2016; 94: 87-91
        • West SL
        • D'Aloisio AA
        • Agans RP
        • et al.
        Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of us women.
        Arch Intern Med. 2008; 168: 1441-1449
        • Avis NE
        • Brockwell S
        • Randolph Jr., JF
        • et al.
        Longitudinal changes in sexual functioning as women transition through menopause: Results from the study of women's health across the nation.
        Menopause. 2009; 16: 442-452
        • Lindau ST
        • Schumm LP
        • Laumann EO
        • et al.
        A study of sexuality and health among older adults in the United States.
        N Engl J Med. 2007; 357: 762-774
        • Shifren JL
        • Monz BU
        • Russo PA
        • et al.
        Sexual problems and distress in United States women: Prevalence and correlates.
        Obstet Gynecol. 2008; 112: 970-978
        • Avis NE
        • Colvin A
        • Karlamangla AS
        • et al.
        Change in sexual functioning over the menopausal transition: Results from the study of women's health across the nation.
        Menopause. 2017; 24: 379-390
        • Parish SJ
        • Nappi RE
        • Krychman ML
        • et al.
        Impact of vulvovaginal health on postmenopausal women: A review of surveys on symptoms of vulvovaginal atrophy.
        Int J Womens Health. 2013; 5: 437-447
        • Worsley R
        • Bell RJ
        • Gartoulla P
        • et al.
        Prevalence and predictors of low sexual desire, sexually related personal distress, and hypoactive sexual desire dysfunction in a community-based sample of midlife women.
        J Sex Med. 2017; 14: 675-686
        • Harder H
        • Starkings RML
        • Fallowfield LJ
        • et al.
        Sexual functioning in 4,418 postmenopausal women participating in ukctocs: A qualitative free-text analysis.
        Menopause. 2019; 26 (1100-009)
        • Laumann EO
        • Waite LJ
        Sexual dysfunction among older adults: Prevalence and risk factors from a nationally representative U.S. Probability sample of men and women 57-85 years of age.
        J Sex Med. 2008; 5: 2300-2311
        • Levine KB
        • Williams RE
        • Hartmann KE
        Vulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women.
        Menopause. 2008; 15: 661-666
        • Simon JA
        • Davis SR
        • Althof SE
        • et al.
        Sexual well-being after menopause: An International Menopause Society white paper.
        Climacteric. 2018; 21: 415-427
        • Castelo-Branco C
        • Palacios S
        • Combalia J
        • et al.
        Risk of hypoactive sexual desire disorder and associated factors in a cohort of oophorectomized women.
        Climacteric. 2009; 12: 525-532
        • Portman DJ
        • Gass ML
        • Vulvovaginal Atrophy Terminology Consensus Conference P
        Genitourinary syndrome of menopause: New terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and the North American Menopause Society.
        Menopause. 2014; 21: 1063-1068
        • American College of Obstericians and Gynecologists' Committee on Practice Bulletins—Gynecology
        Female sexual dysfunction: ACOG practice bulletin clinical management guidelines for obstetrician-gynecologists, number 213.
        Obstet Gynecol. 2019; 134: e1-e18
        • Pfaus JG
        Pathways of sexual desire.
        JSexMed. 2009; 6: 1506-1533
        • Salonia A
        • Giraldi A
        • Chivers ML
        • et al.
        Physiology of women's sexual function: Basic knowledge and new findings.
        J Sex Med. 2010; 7: 2637-2660
        • American Psychiatric Association
        Diagnostic and statistical manual of mental disorders.
        5th ed. 2013: 2013 (Washington D.C.)
        • McCabe MP
        • Sharlip ID
        • Atalla E
        • et al.
        Definitions of sexual dysfunctions in women and men: A consensus statement from the fourth international consultation on sexual medicine 2015.
        J Sex Med. 2016; 13: 135-143
        • Reed GM
        • Drescher J
        • Krueger RB
        • et al.
        Disorders related to sexuality and gender identity in the ICD-11: Revising the ICD-10 classification based on current scientific evidence, best clinical practices, and human rights considerations.
        World Psychiatry. 2016; 15 (Erratum in: World Psychiatry. 2017 Jun;16(2):220): 205-221
        • Simon JA
        • Lukas VA
        Distressing sexual function at midlife: Unmet needs, practical diagnoses, and available treatments.
        Obstet Gynecol. 2017; 130: 889-905
        • Parish SJ
        • Goldstein AT
        • Goldstein SW
        • et al.
        Toward a more evidence-based nosology and nomenclature for female sexual dysfunctions-part II.
        J Sex Med. 2016; 13: 1888-1906
        • Clayton AH
        • Goldfischer ER
        • Goldstein I
        • et al.
        Validation of the decreased sexual desire screener (DSDS): A brief diagnostic instrument for generalized acquired female hypoactive sexual desire disorder (HSDD).
        J Sex Med. 2009; 6: 730-738
        • Hatzichristou D
        • Kirana PS
        • Banner L
        • et al.
        Diagnosing sexual dysfunction in men and women: Sexual history taking and the role of symptom scales and questionnaires.
        J Sex Med. 2016; 13: 1166-1182
        • Rosen R
        • Brown C
        • Heiman J
        • et al.
        The female sexual function index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function.
        J Sex Marital Ther. 2000; 26: 191-208
        • Derogatis L
        • Clayton A
        • Lewis-D'Agostino D
        • et al.
        Validation of the female sexual distress scale-revised for assessing distress in women with hypoactive sexual desire disorder.
        J Sex Med. 2008; 5: 357-364
        • Rogers RG
        • Coates KW
        • Kammerer-Doak D
        • et al.
        A short form of the pelvic organ prolapse/urinary incontinence sexual questionnaire (pisq-12).
        Int Urogynecol J Pelvic Floor Dysfunct. 2003; 14 (Erratum in: Int Urogynecol J Pelvic Floor Dysfunct. 2004 May-Jun;15(3):219): 164-168
        • Annon JS
        The PLISSIT model: A proposed conceptual scheme for the behavioral treatment of sexual problems.
        Journal of Sex Education and Therapy. 1976; 2: 1-15
        • Parish SJ
        • Hahn SR
        • Goldstein SW
        • et al.
        The International Society for the Study of Women's Sexual Health process of care for the identification of sexual concerns and problems in women.
        Mayo Clin Proc. 2019; 94: 842-856
        • Johnston S
        • Bouchard C
        • Fortier M
        • Wolfman W
        Guideline No. 422b: Menopause and Genitourinary Health.
        J Obstet Gynaecol Can. 2021; 43: 1302-1309
        • Orr N
        • Wahl K
        • Joannou A
        • et al.
        Deep dyspareunia: Review of pathophysiology and proposed future research priorities.
        Sex Med Rev. 2020; 8: 3-17
        • Morin M
        • Carroll MS
        • Bergeron S
        Systematic review of the effectiveness of physical therapy modalities in women with provoked vestibulodynia.
        Sex Med Rev. 2017; 5: 295-322
        • Pacik PT
        • Geletta S
        Vaginismus treatment: Clinical trials follow up 241 patients.
        Sex Med. 2017; 5: e114-ee23
        • Davison SL
        • Bell R
        • Donath S
        • et al.
        Androgen levels in adult females: Changes with age, menopause, and oophorectomy.
        J Clin Endocrinol Metab. 2005; 90: 3847-3853
        • Santoro N
        • Worsley R
        • Miller KK
        • et al.
        Role of estrogens and estrogen-like compounds in female sexual function and dysfunction.
        J Sex Med. 2016; 13: 305-316
        • Somboonporn W
        • Davis S
        • Seif MW
        • et al.
        Testosterone for peri- and postmenopausal women.
        Cochrane Database Syst Rev. 2005; CD004509
        • Islam RM
        • Bell RJ
        • Green S
        • et al.
        Safety and efficacy of testosterone for women: A systematic review and meta-analysis of randomised controlled trial data.
        Lancet Diabetes Endocrinol. 2019; 7: 754-766
        • Davis SR
        • Baber R
        • Panay N
        • et al.
        Global consensus position statement on the use of testosterone therapy for women.
        J Clin Endocrinol Metab. 2019; 104: 4660-4666
        • Wierman ME
        • Arlt W
        • Basson R
        • et al.
        Androgen therapy in women: A reappraisal: An Endocrine Society clinical practice guideline.
        J Clin Endocrinol Metab. 2014; 99: 3489-3510
        • Jaspers L
        • Feys F
        • Bramer WM
        • et al.
        Efficacy and safety of flibanserin for the treatment of hypoactive sexual desire disorder in women: A systematic review and meta-analysis.
        JAMA Intern Med. 2016; 176: 453-462
        • Simon JA
        • Kingsberg SA
        • Shumel B
        • et al.
        Efficacy and safety of flibanserin in postmenopausal women with hypoactive sexual desire disorder: Results of the snowdrop trial.
        Menopause. 2014; 21: 633-640
        • Dhillon S
        • Keam SJ
        Bremelanotide: First approval.
        Drugs. 2019; 79: 1599-1606
        • Maserejian NN
        • Shifren J
        • Parish SJ
        • et al.
        Sexual arousal and lubrication problems in women with clinically diagnosed hypoactive sexual desire disorder: Preliminary findings from the hypoactive sexual desire disorder registry for women.
        J Sex Marital Ther. 2012; 38: 41-62
        • Alexander M
        • Bashir K
        • Alexander C
        • et al.
        Randomized trial of clitoral vacuum suction versus vibratory stimulation in neurogenic female orgasmic dysfunction.
        Arch Phys Med Rehabil. 2018; 99: 299-305
        • Kingsberg SA
        • Althof S
        • Simon JA
        • et al.
        Female sexual dysfunction-medical and psychological treatments, committee 14.
        J Sex Med. 2017; 14: 1463-1491
        • Atlantis E
        • Sullivan T
        Bidirectional association between depression and sexual dysfunction: A systematic review and meta-analysis.
        J Sex Med. 2012; 9: 1497-1507
        • Lorenz T
        • Rullo J
        • Faubion S
        Antidepressant-induced female sexual dysfunction.
        Mayo Clin Proc. 2016; 91 (A): 1280-1286
        • Johannes CB
        • Clayton AH
        • Odom DM
        • et al.
        Distressing sexual problems in United States women revisited: Prevalence after accounting for depression.
        J Clin Psychiatry. 2009; 70: 1698-1706
        • Nappi RE
        • Cucinella L
        • Martini E
        • et al.
        Sexuality in premature ovarian insufficiency.
        Climacteric. 2019; 22: 289-295
        • Benetti-Pinto CL
        • Soares PM
        • Giraldo HP
        • et al.
        Role of the different sexuality domains on the sexual function of women with premature ovarian failure.
        J Sex Med. 2015; 12: 685-689
        • Committee on Practice Bulletins—Gynecology
        ACOG practice bulletin no. 126: Management of gynecologic issues in women with breast cancer.
        Obstet Gynecol. 2012; 119: 666-682
        • Tucker PE
        • Bulsara MK
        • Salfinger SG
        • et al.
        Prevalence of sexual dysfunction after risk-reducing salpingo-oophorectomy.
        Gynecol Oncol. 2016; 140: 95-100
        • Baumgart J
        • Nilsson K
        • Evers AS
        • et al.
        Sexual dysfunction in women on adjuvant endocrine therapy after breast cancer.
        Menopause. 2013; 20: 162-168
      1. ACOG committee opinion no. 659 summary: The use of vaginal estrogen in women with a history of estrogen-dependent breast cancer.
        Obstet Gynecol. 2016; 127: 618-619