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Folic Acid Supplementation in Early Pregnancy, Homocysteine Concentration, and Risk of Gestational Diabetes Mellitus

  • Yanfang Guo
    Affiliations
    Better Outcomes Registry & Network Ontario, Ottawa, ON

    Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON

    Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON

    School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON
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  • Rong Luo
    Affiliations
    Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON

    School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON

    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
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  • Daniel J. Corsi
    Affiliations
    Better Outcomes Registry & Network Ontario, Ottawa, ON

    Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON

    Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON

    School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON

    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
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  • Ruth Rennicks White
    Affiliations
    Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON

    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
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  • Graeme Smith
    Affiliations
    Department of Obstetrics and Gynecology, Queen's Perinatal Research Unit, Kingston General Hospital, Queen's University, Kingston, ON
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  • Marc Rodger
    Affiliations
    Department of Medicine, Division of Hematology, University of Ottawa, Ottawa, ON
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  • Ravi Retnakaran
    Affiliations
    Division of Endocrinology and Metabolism, University of Toronto, Toronto, ON

    Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON
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  • Mark Walker
    Affiliations
    Better Outcomes Registry & Network Ontario, Ottawa, ON

    Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON

    School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON

    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
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  • Shi Wu Wen
    Correspondence
    Corresponding author: Shi Wu Wen
    Affiliations
    Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON

    School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON

    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
    Search for articles by this author

      ABSTRACT

      We used a prospective cohort of pregnant women at 12 to 20 weeks gestation between 2002 and 2008 in Ottawa and Kingston to evaluate the impact of early pregnancy folic acid supplementation on the risk of gestational diabetes mellitus. Among 7552 eligible women, 84 (1.11%) were diagnosed of gestational diabetes mellitus. Non-significant associations were observed between gestational diabetes mellitus and folate supplementation, homocysteine levels, and methylenetetrahydrofolate reductase 677 TT genotype. Although we found no significant associations between folic acid supplementation and the risk of gestational diabetes mellitus, genetic associations were not confounded by lifestyle or socioeconomic factors, which may have biased previous studies.

      RÉSUMÉ

      Nous avons utilisé une cohorte prospective de femmes enceintes à 12 à 20 semaines d'aménorrhée entre 2002 et 2008 à Ottawa et à Kingston pour évaluer les effets de la supplémentation en acide folique en début de grossesse sur le risque de diabète sucré gestationnel. Parmi les 7 552 femmes admissibles, 84 (1,11 %) ont reçu un diagnostic de diabète sucré gestationnel. Des associations non significatives ont été observées entre le diagnostic de diabète sucré gestationnel et la supplémentation en acide folique, le taux d'homocystéine et le génotype 677TT du gène de la méthylène tétrahydrofolate réductase. Bien que nous n'ayons observé aucune association significative entre la supplémentation en acide folique et le risque de diabète sucré gestationnel, les associations génétiques étaient indépendantes de facteurs de confusion tels que le mode de vie ou les facteurs socio-économiques, qui pourraient avoir biaisé des études antérieures.

      Keywords

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