Benefits, harms, and costs
Abbreviations:CRL (crown–rump length), NT (nuchal translucency), PI (pulsatility index), SGA (small for gestational age)
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Obstetrics and Gynaecology Canada
- ISUOG practice guidelines: performance of first-trimester fetal ultrasound scan.Ultrasound Obstet Gynecol. 2013; 41: 102-113
- AIUM-ACR-ACOG-SMFM-SRU practice parameter for the performance of standard diagnostic obstetric ultrasound examinations.J Ultrasound Med. 2018; 37: E13-E24
The Fetal Medicine Foundation. Certificates of competency: nuchal translucency scan. Available at: https://fetalmedicine.org/fmf-certification/certificates-of-competence/nuchal-translucency-scan. Accessed on April 14, 2020.
Fong K, Levi C, Mayer L, et al. CAR standard for performing diagnostic obstetric ultrasound examinations. Available at: https://car.ca/wp-content/uploads/Ultrasound-Performing-Diagnostic-Obstetric-Ultrasound-Examinations-2010.pdf. Accessed on January 15, 2021.
- WFUMB/ISUOG statement on the safe use of doppler ultrasound during 11-14 week scans (or earlier in pregnancy).Ultrasound Med Biol. 2013; 39: 373
American Institute of Ultrasound in Medicine. AIUM official statement: as low as reasonably achievable (ALARA) principle. Available at: https://www.aium.org/officialStatements/39. Accessed on April 17, 2020.
- Semi-automated adjusted measurement of nuchal translucency: feasibility and reproducibility.Ultrasound Obstet Gynecol. 2011; 37: 335-340
- Intra-operator and inter-operator reliability of manual and semiautomated measurement of fetal nuchal translucency: a cross sectional study.Prenat Diagn. 2013; 33: 1264-1271
- Guideline No. 388-determination of gestational age by ultrasound.J Obstet Gynaecol Canada. 2019; 41: 1497-1507
- Committee Opinion No. 688: Management of suboptimally dated pregnancies.Obstet Gynecol. 2017; 129: 29-32
- Methods for estimating the due date. Committee opinion 700.Obstet Gynecol. 2017; 129: 959-960
- UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation.Lancet. 1998; 352: 343-346
- Likelihood ratio for trisomy 21 in fetuses with absent nasal bone at the 11-14-week scan.Ultrasound Obstet Gynecol. 2004; 23: 218-223
- Ductus venosus assessment at the time of nuchal translucency measurement in the detection of fetal aneuploidy.Prenat Diagn. 2003; 23: 921-926
- Screening for chromosomal abnormalities at 10-14 weeks: the role of ductus venosus blood flow.Ultrasound Obstet Gynecol. 1998; 12: 380-384
- Tricuspid regurgitation in screening for trisomies 21, 18 and 13 and Turner syndrome at 11 + 0 to 13 + 6 weeks of gestation.Ultrasound Obstet Gynecol. 2009; 33: 18-22
- The nuchal translucency examination leading to early diagnosis of structural fetal anomalies.Early Hum Dev. 2014; 90: 87-91
- Systematic review of first-trimester ultrasound screening for detection of fetal structural anomalies and factors that affect screening performance.Ultrasound Obstet Gynecol. 2017; 50: 429-441
- Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11–13 weeks’ gestation.Ultrasound Obstet Gynecol. 2019; 54: 468-476
- Effectiveness of 12–13-week scan for early diagnosis of fetal congenital anomalies in the cell-free DNA era.Ultrasound Obstet Gynecol. 2018; 51: 463-469
- Long-term psychological consequences of pregnancy termination for fetal abnormality: a cross-sectional study.Prenat Diagn. 2005; 25: 253-260
- Improved detection rate of structural abnormalities in the first trimester using an extended examination protocol.Ultrasound Obstet Gynecol. 2013; 42: 300-309
- How to perform a sonographic morphological assessment of the fetus at 11-14 weeks of gestation.Australas J Ultrasound Med. 2018; 21: 125-137
- First and second trimester screening for fetal structural anomalies.Semin Fetal Neonatal Med. 2018; 23: 102-111
- Outcome of twin pregnancy with two live fetuses at 11–13 weeks’ gestation.Ultrasound Obstet Gynecol. 2020; 55: 32-38
- Relationship of intertwin crown-rump length discrepancy to chorionicity, fetal demise and birth-weight discordance.Ultrasound Obstet Gynecol. 2009; 34: 131-135
- First-trimester growth discordance and adverse pregnancy outcome in dichorionic twins.Ultrasound Obstet Gynecol. 2013; 41: 627-631
- First-trimester ultrasound determination of chorionicity in twin pregnancy.Ultrasound Obstet Gynecol. 2011; 38: 530-532
- First-trimester ultrasound determination of chorionicity in twin gestations using the lambda sign: a systematic review and meta-analysis.Eur J Obstet Gynecol Reprod Biol. 2016; 202: 66-70
- First-trimester risk assessment for trisomies 21 and 18 in twin pregnancy.Am J Obstet Gynecol. 2007; 197 (374 e1-3)
- First trimester aneuploidy screening in the presence of a vanishing twin: implications for maternal serum markers.Prenat Diagn. 2010; 30: 235-240
- Hypertension Guideline Committee. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary.J Obstet Gynaecol Canada. 2014; 36: 416-438
- Uterine artery Doppler at 11 + 0 to 13 + 6 weeks inthe prediction of pre-eclampsia.Ultrasound Obstet Gynecol. 2007; 30: 742-749
- Aspirin versus Placebo in pregnancies at high risk for preterm preeclampsia.N Engl J Med. 2017; 377: 613-622
- Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11–14 weeks of gestation.Ultrasound Obstet Gynecol. 2001; 18: 583-586
- First-trimester uterine artery Doppler and adverse pregnancy outcome: a meta-analysis involving 55 974 women.Ultrasound Obstet Gynecol. 2014; 43: 500-507
- Hypertensive disorders in pregnancy: screening by uterine artery Doppler imaging and blood pressure at 11-13 weeks.Ultrasound Obstet Gynecol. 2009; 34: 497-502
- Competing risks model in early screening for preeclampsia by biophysical and biochemical markers.Fetal Diagn Ther. 2013; 33: 8-15
- Combined screening for preeclampsia and small for gestational age at 11-13 weeks.Fetal Diagn Ther. 2013; 33: 16-27
- Diagnostic accuracy of first-trimester ultrasound in detecting abnormally invasive placenta in high-risk women with placenta previa.Ultrasound Obstet Gynecol. 2018; 52: 258-264
- Screening for morbidly adherent placenta in early pregnancy.Ultrasound Obstet Gynecol. 2019; 53: 101-106
- No. 383-screening, diagnosis, and management of placenta accreta spectrum disorders.J Obstet Gynaecol Canada. 2019; 41: 1035-1049
- Cervical length at 11-14 weeks ’ and 22-24 weeks’ gestation evaluated by transvaginal sonography, and gestational age at delivery.Ultrasound Obstet Gynecol. 2003; 21: 135-139
- Reference ranges for the uterine arteries Doppler and cervical length measurement at 11–13(+6) weeks of gestation in a Brazilian population.J Matern Neonatal Med. 2016; 29: 2909-2914
- Transvaginal sonographic cervical length in first and second trimesters in a low-risk population: a prospective study.Ultrasound Obstet Gynecol. 2018; 51: 604-613
- The role of cervical length measurement at 11-14 weeks for the prediction of preterm delivery.J Matern Neonatal Med. 2011; 24: 465-470
- Prediction of spontaneous preterm delivery from endocervical length at 11 to 13 weeks.Prenat Diagn. 2011; 31: 84-89
- Adnexal masses in pregnancy.Clin Obstet Gynecol. 2009; 52: 570-585
- The value of ultrasound visualization of the ovaries during the routine 11-14 weeks nuchal translucency scan.Eur J Obstet Gynecol Reprod Biol. 2007; 132: 154-158
- Investigation and management of adnexal masses in pregnancy.Scientifica (Cairo). 2016; 2016
This document reflects emerging clinical and scientific advances as of the publication date and is subject to change. The information is not meant to dictate an exclusive course of treatment or procedure. Institutions are free to amend the recommendations. The SOGC suggests, however, that they adequately document any such amendments.
Informed consent: Everyone has the right and responsibility to make informed decisions about their care together with their health care providers. In order to facilitate this, the SOGC recommends that health care providers provide patients with information and support that is evidence-based, culturally appropriate, and personalized.
Language and inclusivity: While the SOGC as a rule uses gendered language, in respect for our mission to advance women's health, there are contexts in which it is important to use gender neutral language, and to be fully inclusive. The SOGC recognizes and respects the rights of all people for whom the information in this document may apply, including but not limited to transgender, non-binary, and intersex people. The SOGC encourages healthcare providers to engage in respectful conversation with their patients about their gender identity and preferred gender pronouns and to apply these guidelines in a way that is sensitive to each person's needs.