ABSTRACT
Animal research strongly suggests that a single dose of antenatal corticosteroids
(ACS) is as effective as a double dose to mature preterm lungs; however, a human randomized
controlled trial (RCT) is urgently needed. From August to November 2020, we conducted
an online survey of Canadian parents of preterm infants. Survey respondents watched
a parent-to-parent video introducing an RCT to study whether the standard double dose
of ACS is non-inferior to a single dose (and matching placebo). Approximately two-thirds
of respondents reported they were either likely or very likely to participate in the
RCT, indicating high parental interest in and support for such a trial.
RÉSUMÉ
La recherche animale suggère fortement qu'une dose unique de corticostéroïdes prénataux (CSP)
est aussi efficace qu'une double dose pour favoriser la maturation des poumons prématurés;
cependant, il est urgent d'effectuer un essai clinique randomisé (ECR) chez l'humain.
D'août à novembre 2020, nous avons mené un sondage en ligne auprès des parents canadiens
de nourrissons prématurés. Les répondants au sondage ont regardé une vidéo de parent
à parent présentant un ECR visant à déterminer si la double dose standard de CSP est
non inférieure à une dose unique (et à un placebo correspondant). Environ les deux
tiers des répondants ont indiqué qu'ils étaient susceptibles ou très susceptibles
de participer à l'ECR, ce qui témoigne d'un intérêt et d'un appui élevés des parents
pour un tel essai.
Keywords
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REFERENCES
- Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis.Lancet Glob Health. 2019; 7: e37-e46
- Perinatal Health Indicators 2013: A Report From the Canadian Perinatal Surveillance System. 2015; (Available at: http://publications.gc.ca/collections/collection_2014/aspc-phac/HP7-1-2013-eng.pdf. Accessed January 28, 2021)
- Highlights of 2011-2012 Selected Indicators Describing the Birthing Process in Canada.CIHI, Ottawa, ON, Canada2013 (Available at: https://secure.cihi.ca/estore/productFamily.htm?pf=PFC2259&lang=en&media=0. Accessed January 28, 2021)
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.Cochrane Database Syst Rev. 2017; 3CD004454
- Prenatal betamethasone exposure and psychopathology risk in extremely low birth weight survivors in the third and fourth decades of life.Psychoneuroendocrinology. 2016; 74: 278-285
- Associations of antenatal glucocorticoid exposure with mental health in children.Psychol Med. 2020; 50: 247-257
- Associations between maternal antenatal corticosteroid treatment and mental and behavioral disorders in children.JAMA. 2020; 323: 1924-1933
- The REDCap consortium: building an international community of software platform partners.J Biomed Inform. 2019; 95103208
- Improving the quality of web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).J Med Internet Res. 2004; 6: e34
Article info
Publication history
Published online: May 06, 2021
Footnotes
Disclosures: The authors declare they have nothing to disclose.
All authors have indicated they meet the journal's requirements for authorship.
Identification
Copyright
© 2021 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.
