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Comparison of the Accuracy of INTERGROWTH-21 and Hadlock Ultrasound Formulae for Fetal Weight Prediction

Published:March 30, 2021DOI:https://doi.org/10.1016/j.jogc.2021.03.015

      ABSTRACT

      Objective

      To compare the accuracy of INTERGROWTH-21 (IG-21) versus Hadlock1 formulae for birth weight prediction on third-trimester ultrasound in a North American population.

      Methods

      This single-centre retrospective cohort study included all pregnant patients who had a third-trimester ultrasound between 340 and 366 weeks gestation and delivered a term singleton at our maternal–fetal medicine reference centre between April 1 and July 30, 2019. Estimated ultrasound fetal weight was calculated with both Hadlock1 and IG-21 formulae for each fetus, then reported on a centile curve to adjust for gestational age at delivery, and compared with the actual birth weight.

      Results

      The cohort included 600 women. The IG-21 formula had a comparable accuracy to Hadlock1 with mean absolute percentage errors (MAPEs) of 8.64 and 8.86, respectively (P = 0.191). Success rate, defined by a <10% discrepancy range of the actual birth weight, was significantly higher for IG-21 than for Hadlock1 (67.5% vs. 64.3%; P = 0.044).

      Conclusion

      Our results do not support the superiority of IG-21 to Hadlock1. There is a need for continued research to improve birth weight prediction with the ultimate objective of increasing the detection of small for gestation age and macrosomic fetuses.

      RÉSUMÉ

      Objectif

      Comparer l'exactitude de prédiction échographique du poids à la naissance de la formule INTERGROWTH-21 (IG-21) et de la formule de Hadlock 1 au troisième trimestre dans une population nord-américaine.

      Méthodologie

      Cette étude rétrospective de cohorte monocentrique inclut toutes les patientes enceintes ayant subi une échographie du troisième trimestre entre 34 SA + 0 j et 36 SA + 6 j et accouché à terme d'une grossesse monofœtale dans notre centre de référence en médecine fœto-maternelle entre le 1er avril et le 30 juillet 2019. Le poids fœtal a été estimé à l’échographie au moyen des formules de Hadlock 1 et IG-21 pour chaque fœtus. Le poids a ensuite été reporté sur une courbe de centiles pour ajuster en fonction de l’âge gestationnel à l'accouchement, puis ce poids ajusté a été comparé au poids réel à la naissance.

      Résultats

      La cohorte comptait 600 femmes. La formule IG-21 avait une précision comparable à celle de la formule Hadlock 1 avec un pourcentage d'erreur absolu moyen de 8,64 et 8,86, respectivement (p = 0,191). Le taux de réussite, défini par un écart de moins de 10 % du poids réel à la naissance, était significativement plus élevé avec la formule IG-21 comparativement à la formule de Hadlock 1 (67,5 % vs 64,3 %; p = 0,044).

      Conclusion

      Nos résultats n'appuient pas la supériorité de la formule IG-21 par rapport à la formule de Hadlock 1. Il est nécessaire de poursuivre les recherches afin d'améliorer la prédiction du poids à la naissance dans l'objectif ultime d'augmenter la détection de l'hypotrophie et de la macrosomie fœtales.

      Keywords

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