Opinion de comité no 407 : Pathologie thyroïdienne et infertilité

      (In English: Thyroid Disease and Infertility)

      Mots clés

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Obstetrics and Gynaecology Canada
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Alexander EK
        • Pearce EN
        • Brent GA
        • et al.
        2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum.
        Thyroid. 2017; 27: 315-389
        • Practice Committee of the American Society for Reproductive Medicine
        Subclinical hypothyroidism in the infertile female population: a guideline.
        Fertil Steril. 2015; 104: 545-553
        • Casey BM
        • Thom EA
        • Peaceman AM
        • et al.
        Treatment of subclinical hypothyroidism or hypothyroxinemia in pregnancy.
        N Engl J Med. 2017; 376: 815-825
        • Wang H
        • Gao H
        • Chi H
        • et al.
        Effect of levothyroxine on miscarriage among women with normal thyroid function and thyroid autoimmunity undergoing in vitro fertilization and embryo transfer: a randomized clinical trial.
        JAMA. 2017; 318: 2190-2198
        • Dhillon-Smith RK
        • Middleton LJ
        • Sunner KK
        • et al.
        Levothyroxine in women with thyroid peroxidase antibodies before conception.
        N Engl J Med. 2019; 380: 1316-1325
        • Yamamoto JM
        • Benham JL
        • Nerenberg KA
        • et al.
        Impact of levothyroxine therapy on obstetric, neonatal and childhood outcomes in women with subclinical hypothyroidism diagnosed in pregnancy: a systematic review and meta-analysis of randomised controlled trials.
        BMJ Open. 2018; 8e022837
        • Lazarus JH
        • Bestwick JP
        • Channon S
        • et al.
        Antenatal thyroid screening and childhood cognitive function.
        N Engl J Med. 2012; 366: 493-501
        • Karmisholt J
        • Andersen S
        • Laurberg P
        Variation in thyroid function in subclinical hypothyroidism: importance of clinical follow-up and therapy.
        Eur J Endocrinol. 2011; 164: 317-323
        • Poppe K
        • Glinoer D
        • Van Steirteghem A
        • et al.
        Thyroid dysfunction and autoimmunity in infertile women.
        Thyroid. 2002; 12: 997-1001
        • Kachuei M
        • Jafari F
        • Kachuei A
        • et al.
        Prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome.
        Arch Gynecol Obstet. 2012; 285: 853-856
        • Monteleone P
        • Parrini D
        • Faviana P
        • et al.
        Female infertility related to thyroid autoimmunity: the ovarian follicle hypothesis.
        Am J Reprod Immunol. 2011; 66: 108-114
        • Ott J
        • Aust S
        • Kurz C
        • et al.
        Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome.
        Fertil Steril. 2010; 94: 2895-2897
        • Thangaratinam S
        • Tan A
        • Knox E
        • et al.
        Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence.
        BMJ. 2011; 342: d2616
        • Cappola AR
        • Casey BM
        Thyroid function test abnormalities during pregnancy.
        JAMA. 2019; 322: 617-619
        • Korevaar TIM
        • Derakhshan A
        • Taylor PN
        • Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth
        Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis.
        JAMA. 2019; 322: 632-641
        • Jatzko B
        • Vytiska-Bistorfer E
        • Pawlik A
        • et al.
        The impact of thyroid function on intrauterine insemination outcome—a retrospective analysis.
        Reprod Biol Endocrinol. 2014; 12: 28
        • Karmon AE
        • Batsis M
        • Chavarro JE
        • et al.
        Preconceptional thyroid-stimulating hormone levels and outcomes of intrauterine insemination among euthyroid infertile women.
        Fertil Steril. 2015; 103 (258–63 e1)
        • Baker VL
        • Rone HM
        • Pasta DJ
        • et al.
        Correlation of thyroid stimulating hormone (TSH) level with pregnancy outcome in women undergoing in vitro fertilization.
        Am J Obstet Gynecol. 2006; 194 (discussion 74–5): 1668-1674
        • Fumarola A
        • Grani G
        • Romanzi D
        • et al.
        Thyroid function in infertile patients undergoing assisted reproduction.
        Am J Reprod Immunol. 2013; 70: 336-341
        • Kim CH
        • Ahn JW
        • Kang SP
        • et al.
        Effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilization/intracytoplasmic sperm injection.
        Fertil Steril. 2011; 95: 1650-1654
        • Negro R
        • Mangieri T
        • Coppola L
        • et al.
        Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: a prospective study.
        Hum Reprod. 2005; 20: 1529-1533
        • Turi A
        • Giannubilo SR
        • Zanconi S
        • et al.
        Preconception steroid treatment in infertile women with antithyroid autoimmunity undergoing ovarian stimulation and intrauterine insemination: a double-blind, randomized, prospective cohort study.
        Clin Ther. 2010; 32: 2415-2421
        • Litwicka K
        • Arrivi C
        • Varricchio MT
        • et al.
        In women with thyroid autoimmunity, does low-dose prednisolone administration, compared with no adjuvant therapy, improve in vitro fertilization clinical results?.
        J Obstet Gynaecol Res. 2015; 41: 722-728
        • Michael AE
        • Papageorghiou AT
        Potential significance of physiological and pharmacological glucocorticoids in early pregnancy.
        Hum Reprod Update. 2008; 14: 497-517
        • Kemp MW
        • Newnham JP
        • Challis JG
        • et al.
        The clinical use of corticosteroids in pregnancy.
        Hum Reprod Update. 2016; 22: 240-259

      Linked Article

      • Committee Opinion No. 407: Thyroid Disease and Infertility
        Journal of Obstetrics and Gynaecology Canada Vol. 42Issue 10
        • Preview
          In 2017, the American Thyroid Association (ATA) published guidelines for the diagnosis and management of thyroid disease during pregnancy,1 including 3 pages devoted to the impact of thyroid disease on infertility and assisted reproduction. The American Society for Reproductive Medicine (ASRM) also published a guideline on subclinical hypothyroidism and infertility in 2015.2 However, neither the ATA nor the ASRM recommendations have high-quality evidence supporting them. To date, the American College of Obstetricians and Gynecologists and Society of Obstetricians and Gynaecologists of Canada have not published their own recommendations on the screening and management of thyroid disease in women with infertility or undergoing assisted reproduction.
        • Full-Text
        • PDF