Abstract
Background
Pregnancy in patients with amyotrophic lateral sclerosis (ALS) is extremely rare and
often results in delivery of a healthy baby when patients are in the early stages
of the disease.
Case
This report describes the case of a successful pregnancy 5 years after ALS onset.
Significant worsening of weakness, unsteady balance, and dysphagia were noticed around
the third trimester. A healthy child was delivered at term by planned Caesarean section.
After delivery the patient developed remarkable weakness, dysphagia, and dysarthria.
Conclusion
A literature search found 22 cases through PubMed and Ovid, with key words “amyotrophic
lateral sclerosis” and “pregnancy.” Both slow progression and rapid progression of
ALS during pregnancy have been reported. Worsening of symptoms seems to be common,
but little is still known about the influence of pregnancy on ALS onset and progression.
Résumé
Contexte
Les grossesses chez des patientes atteintes de sclérose latérale amyotrophique (SLA)
sont extrêmement rares, mais se soldent souvent par l'accouchement d'un bébé en santé
lorsque la patiente est à un stade précoce de la maladie.
Cas
Ce rapport présente le cas d'une grossesse réussie, cinq ans après le déclenchement
de la SLA. Une aggravation importante de la faiblesse, des problèmes d'équilibre et
de la dysphagie a été observée vers le troisième trimestre. La patiente a accouché
à terme d'un bébé en santé par césarienne planifiée. Après l'accouchement, elle présentait
une faiblesse, une dysphagie et une dysarthrie importantes.
Conclusion
Une recherche dans PubMed et dans l'interface Ovid, à l'aide des mots-clés ≪ amyotrophic
lateral sclerosis ≫ (sclérose latérale amyotrophique) et ≪ pregnancy ≫ (grossesse)
a permis de recenser 22 cas. Des progressions lentes et rapides de la SLA ont été
rapportées durant la grossesse. L'aggravation des symptômes semble être fréquente,
mais nous en savons peu actuellement sur les conséquences d'une grossesse sur le déclenchement
et la progression de la SLA.
Key Words
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Article info
Publication history
Published online: December 07, 2018
Accepted:
August 24,
2018
Footnotes
Competing interests: See Acknowledgements.
Each author has indicated that they meet the journal's requirements for authorship.
Identification
Copyright
© 2018 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.
