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Pregnancy 5 Years After Onset of Amyotrophic Lateral Sclerosis Symptoms: A Case Report and Review of the Literature

Published:December 07, 2018DOI:https://doi.org/10.1016/j.jogc.2018.09.015

      Abstract

      Background

      Pregnancy in patients with amyotrophic lateral sclerosis (ALS) is extremely rare and often results in delivery of a healthy baby when patients are in the early stages of the disease.

      Case

      This report describes the case of a successful pregnancy 5 years after ALS onset. Significant worsening of weakness, unsteady balance, and dysphagia were noticed around the third trimester. A healthy child was delivered at term by planned Caesarean section. After delivery the patient developed remarkable weakness, dysphagia, and dysarthria.

      Conclusion

      A literature search found 22 cases through PubMed and Ovid, with key words “amyotrophic lateral sclerosis” and “pregnancy.” Both slow progression and rapid progression of ALS during pregnancy have been reported. Worsening of symptoms seems to be common, but little is still known about the influence of pregnancy on ALS onset and progression.

      Résumé

      Contexte

      Les grossesses chez des patientes atteintes de sclérose latérale amyotrophique (SLA) sont extrêmement rares, mais se soldent souvent par l'accouchement d'un bébé en santé lorsque la patiente est à un stade précoce de la maladie.

      Cas

      Ce rapport présente le cas d'une grossesse réussie, cinq ans après le déclenchement de la SLA. Une aggravation importante de la faiblesse, des problèmes d'équilibre et de la dysphagie a été observée vers le troisième trimestre. La patiente a accouché à terme d'un bébé en santé par césarienne planifiée. Après l'accouchement, elle présentait une faiblesse, une dysphagie et une dysarthrie importantes.

      Conclusion

      Une recherche dans PubMed et dans l'interface Ovid, à l'aide des mots-clés ≪ amyotrophic lateral sclerosis ≫ (sclérose latérale amyotrophique) et ≪ pregnancy ≫ (grossesse) a permis de recenser 22 cas. Des progressions lentes et rapides de la SLA ont été rapportées durant la grossesse. L'aggravation des symptômes semble être fréquente, mais nous en savons peu actuellement sur les conséquences d'une grossesse sur le déclenchement et la progression de la SLA.

      Key Words

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