CASE REPORT| Volume 41, ISSUE 1, P72-75, January 2019

Anaplastic Carcinoma Arising From Ovarian Mucinous Adenocarcinoma With Massive Cardiopulmonary Metastasis: An Autopsy Case Report

Published:November 01, 2018DOI:



      The presence of anaplastic and sarcomatoid components in ovarian mucinous carcinoma is extremely rare.


      A 64-year-old woman underwent radical surgery for right ovarian cancer. Pathological examination showed mucinous adenocarcinoma with a focal mural nodule of anaplastic and sarcomatoid carcinoma (FIGO stage IIB). She underwent adjuvant chemotherapy but developed severe respiratory failure and died after 9 months. Autopsy showed that the bilateral pulmonary parenchyma was filled with a multinodular hemorrhagic mass, and the cardiac wall had a massive invasive lesion. Histopathological examination of the lung and myocardium revealed diffuse invasion of the anaplastic carcinoma component with infiltrating osteoclastic giant cells.


      This case is very rare, and the clinical management of anaplastic carcinoma arising in mucinous neoplasms remains challenging.



      La présence de composantes anaplasiques et sarcomatoïdes dans un carcinome mucineux de l'ovaire est extrêmement rare.


      Une femme de 64 ans a subi une chirurgie radicale pour un cancer de l'ovaire droit. L'examen pathologique a montré un adénocarcinome mucineux avec un nodule mural local de carcinome anaplasique et sarcomatoïde (stade IIB de la FIGO). Après avoi subi une chimiothérapie adjuvante, elle a développé une insuffisance respiratoire grave et est décédée neuf mois plus tard. L'autopsie a montré un parenchyme pulmonaire bilatéral rempli d'une masse hémorragique multinodulaire, et une lésion invasive importante dans la paroi du cœur. L'examen histopathologique du poumon et du myocarde a révélé une invasion diffuse de la composante anaplasique avec une infiltration d'ostéoclastes géants.


      Ce cas est très rare, et la prise en charge clinique du carcinome anaplasique issu d'un néoplasme mucineux demeure un défi.

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