Abstract
Background
The presence of anaplastic and sarcomatoid components in ovarian mucinous carcinoma
is extremely rare.
Case
A 64-year-old woman underwent radical surgery for right ovarian cancer. Pathological
examination showed mucinous adenocarcinoma with a focal mural nodule of anaplastic
and sarcomatoid carcinoma (FIGO stage IIB). She underwent adjuvant chemotherapy but
developed severe respiratory failure and died after 9 months. Autopsy showed that
the bilateral pulmonary parenchyma was filled with a multinodular hemorrhagic mass,
and the cardiac wall had a massive invasive lesion. Histopathological examination
of the lung and myocardium revealed diffuse invasion of the anaplastic carcinoma component
with infiltrating osteoclastic giant cells.
Conclusion
This case is very rare, and the clinical management of anaplastic carcinoma arising
in mucinous neoplasms remains challenging.
Résumé
Contexte
La présence de composantes anaplasiques et sarcomatoïdes dans un carcinome mucineux
de l'ovaire est extrêmement rare.
Cas
Une femme de 64 ans a subi une chirurgie radicale pour un cancer de l'ovaire droit.
L'examen pathologique a montré un adénocarcinome mucineux avec un nodule mural local
de carcinome anaplasique et sarcomatoïde (stade IIB de la FIGO). Après avoi subi une
chimiothérapie adjuvante, elle a développé une insuffisance respiratoire grave et
est décédée neuf mois plus tard. L'autopsie a montré un parenchyme pulmonaire bilatéral
rempli d'une masse hémorragique multinodulaire, et une lésion invasive importante
dans la paroi du cœur. L'examen histopathologique du poumon et du myocarde a révélé
une invasion diffuse de la composante anaplasique avec une infiltration d'ostéoclastes
géants.
Conclusion
Ce cas est très rare, et la prise en charge clinique du carcinome anaplasique issu
d'un néoplasme mucineux demeure un défi.
Key Words
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References
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Article info
Publication history
Published online: November 01, 2018
Accepted:
July 9,
2018
Received:
February 27,
2018
Footnotes
Competing interests: See Acknowledgements.
Identification
Copyright
© 2018 Society of Obstetricians and Gynaecologists of Canada. Published by Elsevier Inc. All rights reserved.
