Abstract
Objective
Intended Users
Target Population
Options
Outcomes
Evidence
Values
Benefits, Harms, and/or Costs
Updates
Sponsors
Recommendations
- 1.Fesoterodine is recommended as a treatment for overactive bladder (Strong, High).
- 2.Dose escalation of fesoterodine is recommended for improved clinical efficacy, as it is associated with significant subjective and objective clinical improvement, both short and long term (Strong, High).
- 3.Fesoterodine is recommended as an anticholinergic of choice for overactive bladder symptoms in elderly and frail elderly (Strong, High).
- 4.Fesoterodine is recommended for overactive bladder symptoms in patients with pre-existing cardiac concerns or cognitive dysfunction (Strong, Moderate).
- 5.Fesoterodine is recommended for nocturnal overactive bladder symptoms to improve sleep quality (Conditional, High).
- 6.Mirabegron is recommended as a treatment for overactive bladder (Conditional, High).
- 7.Mirabegron is recommended for overactive bladder symptoms in patients with intolerable side effects or suboptimal response on anticholinergic therapy (Strong, Moderate).
- 8.Mirabegron may be used in combination with solifenacin 5 mg for overactive bladder symptoms as an alternative to solifenacin 10 mg to decrease anticholinergic side effects of the higher dose solifenacin (Conditional, High).
Key Words
Abbreviations:
CNS (central nervous system), FORTA (Fit fOR The Aged), OAB (overactive bladder syndrome), RCT (randomized control trial)Purchase one-time access:
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