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Abstract
Objective: to assess the efficacy of highly purified follicle stimulating hormone (HP-FSH) compared to human menopausal gonadotrophin (hMG) in in vitro fertilization (IVF).
Design: open, prospective, randomized parallel group, comparative, multicentre study.
Setting: one private and one public institution.
Patient: infertile population undergoing in vitro fertilization.
Outcome of interest: ovarian response to drugs: birth rate.
Results: increased number of follicles, oocytes and embryos in HP-FSH group and comparable birth rates.
Conclusions: use of HP-FSH in IVF offers similar success rates to hMG. Subcutaneous administration makes HP-FSH simpler for both patients and medical staff.
Résumé
Objectif : Comparer l’efficacité de la HP-FSH au hMG (Pergonal) en FIV.
Forme: Étude comparative, randomisée, prospective et multicentrique.
Cadre: Institutions privée (1) et publique (1).
Patients: Population infertile en fécondation in vitro.
Points d’interet: Réponse ovarienne.
Résultats: Un nombre significativement plus élevé de follicules, d’ovules et d’embryons ont été obtenus dans le groupe HP-FSH comparativement au groupe hMG. Les taux de naissance sont comparables.
Conclusions: L’utilisation de HP-FSH en FIV offre des taux comparables de naissance à l’hMG. L’administration sous-cutanée de HP-FSH rend la stimulation ovarienne plus simple pour les patientes et l’équipe médicale.
Key Words
References
- Composition of commercial gonadotrophin preparations extracted from human post-menopausal urine: characterization of nongonadotrophin proteins.Hum Reprod. 1994; 9: 2291-2299
- Multiple follicular development and ovarian steroidogenesis following subcutaneous administration of a highly purified urinary FSH preparation in pituitary desensitized women undergoing IVF: a multicentre European phase III study.Hum Reprod. 1994; 9: 424-430
- Simplification of IVF: minimal monitoring and the use of subcutaneous highly purified FSH administration for ovulation induction.Hum Reprod. 1994; 9: 1430-1436
- Follicle-stimulating hormone versus menopausal gonadotropin for in vitro fertilization cycles: a meta-analysis.Fertil Steril. 1995; 64: 347-354
- Pure and highly purified follicle-stimulating hormone alone or in combination with human menopausal gonadotrophin for ovarian stimulation after pituitary suppression in in vitro fertilization.Hum Reprod. 1996; 11: 2400-2404
Article info
Publication history
Accepted:
August 25,
1997
Received in revised form:
August 25,
1997
Received:
July 5,
1997
Identification
Copyright
© 1998 Published by Elsevier Inc.
