Research Article| Volume 20, ISSUE 3, P283-288, March 1998

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Comparison between Highly Purified-FSH and hMG for Superovulation in Women undergoing in vitro Fertilization

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      Objective: to assess the efficacy of highly purified follicle stimulating hormone (HP-FSH) compared to human menopausal gonadotrophin (hMG) in in vitro fertilization (IVF).
      Design: open, prospective, randomized parallel group, comparative, multicentre study.
      Setting: one private and one public institution.
      Patient: infertile population undergoing in vitro fertilization.
      Outcome of interest: ovarian response to drugs: birth rate.
      Results: increased number of follicles, oocytes and embryos in HP-FSH group and comparable birth rates.
      Conclusions: use of HP-FSH in IVF offers similar success rates to hMG. Subcutaneous administration makes HP-FSH simpler for both patients and medical staff.


      Objectif : Comparer l’efficacité de la HP-FSH au hMG (Pergonal) en FIV.
      Forme: Étude comparative, randomisée, prospective et multicentrique.
      Cadre: Institutions privée (1) et publique (1).
      Patients: Population infertile en fécondation in vitro.
      Points d’interet: Réponse ovarienne.
      Résultats: Un nombre significativement plus élevé de follicules, d’ovules et d’embryons ont été obtenus dans le groupe HP-FSH comparativement au groupe hMG. Les taux de naissance sont comparables.
      Conclusions: L’utilisation de HP-FSH en FIV offre des taux comparables de naissance à l’hMG. L’administration sous-cutanée de HP-FSH rend la stimulation ovarienne plus simple pour les patientes et l’équipe médicale.

      Key Words


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