Research Article| Volume 18, ISSUE 10, P1051-1060, 1996

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Efficacité de l’aspirine à faible dose au cours de la grossesse en fonction des facteurs de risque maternels et foetaux

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      Low-dose aspirin (50 to 150 mg) improves the imbalance between prostacyclin and thromboxane which is observed in proteinuric pre-eclamsia and intra-uterine growth restriction. The stratification of the published clinical trials according to the maternal and fetal risk level suggests that this drug may be effective in preventing proteinurie pre-eclampsia and intra-uterine growth restriction only in women at high risk for these complications. However, low-dose aspirin does not reduce the incidence of pregnancy-induced hypertension and perinatal mortality, and does not influence the clinical course of established pre-eclampsia. The drug should be begun before 28 weeks of pregnancy and could be taken until delivery. Low-dose aspirin is safe for the mother and the newborn infant.


      L’aspirine à faible dose (50 à 150 mg) corrige le déséquilibre entre la prostacycline et le thromboxane qui existe dans la pré-éclampsie et le retard de croissance intra-utérin. L’analyse des études cliniques en fonction du niveau de risque suggère que l’aspirine à faible dose prévient la pré-éclampsie avec protéinurie et le retard de croissance intra-utérin uniquement chez les femmes ayant un risque élevé de présenter ces complications. Par contre, elle ne diminue pas l’incidence d’hypertension artérielle induite par la grossesse sans protéinurie et la mortalité périnatale et ne modifie pas l’évolution clinique de la pré-éclampsie. L’aspirine doit être commencée avant 28 semaines et peut être prise jusqu’à l’accouchement. L’aspirine à faible dose semble sans danger pour la mère et le nouveau-né.

      Key Words


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